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Amniotic Band Syndrome

Definition

Formation of fibrous bands that entrap fetal parts
Incidence 1:1200 pregnancies
Diagnosis Ultrasound features of assymmetrical abnormalities including sever craniofacial abnormalities, chest wall abnormalitiesm, abdominal defects and limb abnormalities with or without multiple thin membranes "floating" in amniotic fluid
Gestation at diagnosis 12 weeks onwards
Known cause, chromosomal or genetic association Usually sporadic, very rarely associated with Ehlers-Danlos syndrome
Further investigations None
Differential Diaganosis Other causes of anatomical defects (e.g. Gastroschisis etc.)
Prognosis Dependent on area of fetus involved, can be poor if significant disruption to excellent if isloated digits
Recurrance risk Very low
Research Studies None

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