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Cytomegalovirus (CMV) infection
Definition |
Viral infection that usually produces mild symptoms in mother, but can cause significant abnormalities in the fetus |
| Incidence | 1:100 |
| Diagnosis | Ultrasound appearances can be variable and include
|
| Gestation at diagnosis | 18 weeks onwards |
| Known cause, chromosomal or genetic association | Caused by cytomegalovirus infection in mother. If primary infection in mother 30-40% transmission to fetus. If secondary infection 0.2-8% transmission. |
| Further investigations | Maternal blood test for TORCH+Parvo. Consider amniocentesis for viral load. |
| Differential Diaganosis | Parvovirus infection Toxoplasmosis infecetion Varicella infection Herpes simplex infection Syphilis infection Rubella infection Other cause of Echogenic bowel |
| Prognosis | 10% of congenitally infected infants symptomatic at birth, up to 90% will have some neurological consequences (see information leaflet). Of the remainig 90% asymptomatic infants 10-15% will develop sequelae later in child hood (commonest deafness). |
| Recurrance risk | Low |
| Research Studies |
Further information for clinicians please click here
Patient information leaflet please click here
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