Leeds Fetal Medicine Unit Website

Microcephaly

Definition	Head circumference >3SD below the mean for gestational age
Incidence	1.6/1000
Diagnosis	Ultrasound (usually serial)
Gestation at diagnosis	~18 weeks
Known cause, chromosomal or genetic association	Yes - Infection (Toxoplasmosis, CMV, Rubella), chromosomal (Trisomy 13,18), syndromal (usually autosomal recessive)
Further investigations	Infection screen, Karyotype, MRI
Differential Diaganosis	Craniosynostosis
Prognosis
Recurrance risk	Dependent on cause
Research Studies

Further information for clinicians please click here

Patient information leaflet please click here

Links

If you have techinical problems with this website please contact webmaster@leedsth.nhs.uk.