Leeds Fetal Medicine Unit Website

Situs Invertus

Definition	Heart and Stomach on right
Incidence	~3/1000 second trimester scans
Diagnosis	Ultrasound
Gestation at diagnosis	11-12 weeks
Known cause, chromosomal or genetic association	Chromosomes usually normal, but is associated with Kartagener's syndrome (20% of cases, condition is autosomally recessive)
Further investigations	Fetal Echocardiogram
Differential Diaganosis	Displaced heart due to chest abnormality (eg CAM) Heterotaxy syndromes (comples congenital heart disease and midline liver)
Prognosis	Excellent unless associated with syndrome
Recurrance risk	Low unless Kartagener's
Research Studies	None

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