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Leeds Fetal Medicine Unit Website

 

Tetralogy of Fallot

Definition	Congenital heart disease with four components Right ventricular outflow tract obstruction Ventricular septal defect Overriding aorta Right ventricular hypertrophy
Incidence	0.2-0.5/1000 livebirths (5-10% of congenital heart disease)
Diagnosis	Ultrasound
Gestation at diagnosis	18-22 weeks
Known chromosomal or genetic association	Yes, Trisomy 21, 18, 13, 22q11 deletion syndromes (10% of cases)
Further investigations	Karyotype and Fetal Echocardiogram
Differential Diaganosis	VSD Double outlet right ventricle Pulmonary atresia with VSD
Prognosis	If isolated good >95%
Recurrance risk	2.5%
Research Studies	None

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