Leeds Fetal Medicine Unit Website

Toxoplasmosis

Definition	Transplacental infection with the protozoan Toxoplasma gondii
Incidence	Unknown in UK
Diagnosis	Ultrasound features including Random calcifications particularly intracranial IUGR Echogenic bowel Ventriculomegaly
Gestation at diagnosis	18 weeks onwards
Known cause, chromosomal or genetic association	Toxoplasma gondii
Further investigations	TORCH+parvovirus maternal blood screen.
Differential Diaganosis	Other congential infections Other causes of echogenic bowel
Prognosis	If infection occurs in first trimester likely outcome miscarriage or severe abnormalities (transmission 2-10% of cases). If later in pregnancy higher chance of congenital infection, but lower chance of abnormalities. If brain looks normal on ultrasound outlook is good.
Recurrance risk	Very low
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